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JASCO has developed a high throughtput preparative SFC system. The heart of the system is SF-Nav software which controls the fractionation system and allows up to 8 large fractions to be collected. A 120mL/min CO2 pump coupled to a 20mL/min or 60mL/min modifier pump drives the system.
- Separation and purification from hundreds of milligrams to several grams with up to 30 mm I.D. columns
- Preparative scale CO2 delivery up to 120mL/min
- Fraction collection of up to 8 fractions
- SF-Nav Dedicated software for high throughput stack injection
Sampling
Sample injection using manual valve or large volume autosampler
Fractionation
The purpose designed cabinet contains up to 8 fractionation vessles and manifold under the control of SF-Nav software. Collection can be selected by time, signal level and/or slope as standard. In addition, spectral purity monitoring of Chiral molecules using the g-factor output of the CD detector is standard with the CD detector option.
Column Capacity
Up to 20 mm x 250 mm columns can be accommodated in the column oven while 30mm and larger columns can be used outside the oven. |
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Optional detectors include
- UV-Visible Detector
- UV-Visible Multiwavelength
- Photometric Diode Array
- Chiral Detectors
Flow cells are rated up to 300 MP (Bar)
SF-Nav for Preparative SFC/E
SF-NAV controls and process management of SFE systems and preparative SFC systems. In addition to pumps, autosamplers, and detectors, it can also control automatic back-pressure valves and fractionation. SF-NAV can monitor and save information such as temperature, pressure, and CO2 flow within the system during preparative isolation and the extraction process, making it useful when investigating fractionation and extraction conditions. It can also set fractionation and extraction conditions in line with the slope and threshold values of signals obtained from detectors and other devices, enabling full process automation for preparative isolation and extraction.
SF-Nav also displays the operation state of units, icons that invoke processes by sample, and a monitor screen for chromatograms. This makes work related to SFE and preparative SFC easy to understand. Batch save parameters including chromatograms, temperature, pressure, and CO2 flow and export them in ASCII format.
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